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Centrifugal filters are used in laboratory settings to manipulate peptides, proteins, oligonucleotides, DNA, and RNA samples. The devices successfully clean up labeling and PCR reactions, isolate specific sections, buffer exchange, clarify samples, and remove particulates. Filters with nylon membrane are ideal for prefiltration clean-up of large agarose or acrylamide gel debris prior to purification with an MWCO device. The centrifugal filters will meet concentration, purification, separation and desalting procedure requirements.