CTGrade GMP rh IL-7 is a recombinant human protein that is produced from E. coli and is designed to support basic, translational, and clinical research, as well as commercial applications.
- High biological activity verified by a relevant bioactivity assay
- Low endotoxin levels
- ≥97% purity
- High lot-to-lot consistency
IL-7 promotes the stimulation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells. IL-7, along with IL-2, 15, and 21, is a member of the common gamma (γc) chain cytokine family. Secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes. Signals through its receptor (IL-7R) to promote the differentiation of hematopoietic stem cells into T cells, B cells, and natural killer cells. Is a regulator of intestinal mucosal lymphocyte proliferation.
Promotes favorable phenotypes in adoptive cellular therapies such as CAR-T cell therapy when combined with IL-15. The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance. The CTGrade GMP products are manufactured in a facility that does not use or process beta-lactam containing materials. No animal- or human-derived materials were used during manufacturing or as ingredients.
- Conjugation:Unconjugated
- Protein Function:Cytokine
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Storage Conditions:At or below –20 °C
- Endotoxin Content:Endotoxin LAL (EU/µg) ≤0.05
- Biological Activity:Bioactivity assay: Proliferation using PHA-activated PBMC, ED50 ≤0.5 ng/ml, Bioactivity ≥1.2x10⁵ IU/µg
- Gene ID:P13232
- Reconstitution Instructions:Sterile water at 0.1 - 0.5 mg/ml
- Endotoxin-free:N
- Carrier-Free:Y
- Protease-free:N
- Animal-Free:Y
- Protein Synonyms:Lymphopoietin 1 (LP-1)|pre-B cell Factor
- Protein/Peptide Name:IL-7
- Purity:≥97%
- Molecular Weight:17.5 kDa
- Sequence:MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH
- Endotoxin Level:Low
- Formulation:20 mM sodium phosphate, pH 7.5
- Nuclease-free:N
- Grade:CTGrade GMP
- Shipping Temperature:Ambient
- Tested Applications:Bioassay
- Pack typeSizeOrigin
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