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- Antibody Type:Primary
- Antigen Name:THOC2
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human
- Western Blot:Yes
- Size:100 µl
- Epitope:101-200/1593
- Form:Liquid
- Gene ID:57187
- Antigen Synonyms:hTREX120|THO2|CXorf3|dJ506G2.1|THOC2|THO complex subunit 2
- Modification:Unmodified
- Storage Buffer:Aqueous buffered solution containing 0.01 M TBS (pH 7,4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- Molecular Weight:175 kDa
- Storage Temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze–thaw cycles.
- Concentration:1 µg/µl
- Shipping Temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human THOC2
- Tested Applications:ICC
- Purification:Purified by Protein A
- Cat. No.:76100-646
- Packaging:Vial
Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim.
Type: Primary
Antigen: THOC2
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 101-200/1593
Host: Rabbit
Isotype: IgG
Reactivity: Human