Colistin is a polymyxin antibiotic, it is a mixture of cyclic polypeptides colistin A and B. Colistin is effective against most Gram-negative bacilli and is used as a polypeptide antibiotic.
- Storage temperature: +4 °C, desiccate
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH.
Colistin sulphate is used to permeabilise bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms, such as A. baumannii. It has been used to study hephrotoxicity in the rat kidney, and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa.
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- CAS No.:1066-17-7
1264-72-8 - Biological Activity:≥15,000 U/mg
- Form:Off-white powder
- MDL No.:MFCD00146495
- Protein Synonyms:Polymyxin E sulfate salt
- Protein/Peptide Name:Colistin sulphate
- Solubility:Soluble in water (50 mg/mL).
- Molecular Formula:C₁₀₄H₂₀₆N₃₂O₄₆S₅
- Pack typeSizeSupplier no.
- 0219415725Bottle25 mg0219415725Each (25mg)$45.60
- 0219415783Bottle250 mg0219415783Each (250mg)$137.32