SPLINTR® Ligase, New England Biolabs

Supplier: New England Biolabs
M0375S M0375L M0375S M0375L
102877-586EA 108.65 USD
CA102877-584 CA102877-586 102877-586 102877-584
SPLINTR® Ligase, New England Biolabs
Nucleic Acid Reagents Cloning Kits and Ligation
SplintR Ligase, also known as PBCV-1 DNA Ligase or Chorella virus DNA Ligase, efficiently catalyzes the ligation of adjacent, single-stranded DNA oligonucleotides splinted by a complementary RNA strand.

This previously unreported activity may enable novel approaches for characterization of miRNAs and mRNAs, including SNPs. SplintR is ideally suited for many target enrichment workflows with applications in next-generation sequencing and molecular diagnostics. The robust activity of the enzyme and its affinity for RNA-splinted DNA substrates (apparent Km = 1 nM) enable sub-nanomolar detection of unique RNA species within a complex mixture, making SplintR ligase a superior choice for demanding RNA detection technologies.
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