The BC96 antibody is specific for human CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Signaling via CD25 may modulate Th17 and Treg cell differentiation, and has been shown to play a role in the function of dendritic cells.
The BC96 antibody may be used as a marker for expression of CD25 during T and B cell development, on activated mature T and B cells, and for its expression at high levels on natural T regulatory cells (nTreg cells) in the thymus or periphery, and on “induced” peripheral Tregs. This antibody is cross-reactive with CD25 in several non-human species, including Baboon, Chimpanzee, Cynomolgus and Rhesus.
Type: Primary
Antigen: IL2RA
Clonality: Monoclonal
Clone: BC96
Conjugation: PE (Phycoerythrin)-Cy7®
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Baboon, Chimpanzee, Cynomolgus, Rhesus
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- Catalog No:
- 10051-476
- 10051-478
- Antigen Symbol:
- IL2RA
- IL2RA
- Antigen Name:
- Interleukin 2 Receptor, Alpha
- Interleukin 2 Receptor, Alpha
- Antigen Synonyms:
- TCGFR|IL2-RA|p55|IL-2R subunit alpha|IL-2 receptor subunit alpha|IL-2-RA|IL2R|TAC antigen|IDDM10|CD25
- TCGFR|IL2-RA|p55|IL-2R subunit alpha|IL-2 receptor subunit alpha|IL-2-RA|IL2R|TAC antigen|IDDM10|CD25
- Antibody Type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- PE (Phycoerythrin)-Cy7®
- PE (Phycoerythrin)-Cy7®
- Clone:
- BC96
- BC96
- Reactivity:
- Baboon, Cynomolgus monkey, Macaque, Chimpanzee, Human
- Baboon, Cynomolgus monkey, Macaque, Chimpanzee, Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 3559
- 3559
- Isotype:
- IgG1
- IgG1
- Flow Cytometry:
- Yes
- Yes
- Neutralisation:
- Yes
- Yes
- Storage Temperature:
- Store undiluted at 2-8°C, protect from light, do not freeze.
- Store undiluted at 2-8°C, protect from light, do not freeze.
- Shipping Temperature:
- Store undiluted at 2...8 °C, protect from light, do not freeze.
- Store undiluted at 2...8 °C, protect from light, do not freeze.
- Tested Applications:
- Flow Cytometry
- Flow Cytometry
- SizeSupplier no.
Specifications
Antigen SymbolIL2RAAntigen NameInterleukin 2 Receptor, AlphaEnvironmentally PreferableAntigen SynonymsTCGFR|IL2-RA|p55|IL-2R subunit alpha|IL-2 receptor subunit alpha|IL-2-RA|IL2R|TAC antigen|IDDM10|CD25Antibody TypePrimaryClonalityMonoclonalConjugationPE (Phycoerythrin)-Cy7®CloneBC96ReactivityBaboon, Cynomolgus monkey, Macaque, Chimpanzee, HumanHostMouseGene ID3559IsotypeIgG1Flow CytometryYesNeutralisationYesStorage TemperatureStore undiluted at 2-8°C, protect from light, do not freeze.Shipping TemperatureStore undiluted at 2...8 °C, protect from light, do not freeze.Tested ApplicationsFlow CytometrySpecifications
Antigen SymbolIL2RAAntigen NameInterleukin 2 Receptor, AlphaEnvironmentally PreferableAntigen SynonymsTCGFR|IL2-RA|p55|IL-2R subunit alpha|IL-2 receptor subunit alpha|IL-2-RA|IL2R|TAC antigen|IDDM10|CD25Antibody TypePrimaryClonalityMonoclonalConjugationPE (Phycoerythrin)-Cy7®CloneBC96ReactivityBaboon, Cynomolgus monkey, Macaque, Chimpanzee, HumanHostMouseGene ID3559IsotypeIgG1Flow CytometryYesNeutralisationYesStorage TemperatureStore undiluted at 2-8°C, protect from light, do not freeze.Shipping TemperatureStore undiluted at 2...8 °C, protect from light, do not freeze.Tested ApplicationsFlow Cytometry