Mca-(Ala⁷,Lys(Dnp)⁹)-Bradykinin Trifluoroacetate

About this item

Substrate V, Mca-RPPGFSAFK(Dnp), is a very sensitive internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1) a membrane-bound zinc metallopeptidase that is related to neprilysin in amino acid sequence. The kcat/Km value for the hydrolysis by ECE-1 was 1.9 x 10⁷ M⁻¹s⁻¹ and 1.7 x 10⁶ M⁻¹s⁻¹ for the hydrolysis by neprilysin. This FRET substrate was hydrolyzed rapidly by stromelysin 1 (MMP-3) with kcat/Km= 218000 M⁻¹s⁻¹ and very slowly by gelatinase B (MMP-9) (kcat/Km= 10100 M⁻¹s⁻¹). There was no hydrolysis by MMP-1 and MMP-2. Mca-RPPGFSAFK(Dnp) has also found use as substrate for insulin-degrading enzyme (IDE) and ACE2.

CAS No.:
323577-36-2
Storage Conditions:
–20 ± 5 °C
MDL No.:
MFCD18782552
Protein/Peptide Name:
Mca-(Ala⁷,Lys(Dnp)⁹)-Bradykinin Trifluoroacetate
Molecular Weight:
1388.46
Sequence:
Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH
Molecular Formula:
C₆₆H₈₁N₁₅O₁₉

Product Information

Catalog #
Supplier #
Size
Supplier no.
Availability
Price
M-2405.0001BA
4029459.0001
1 mg
M-2405.0001
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Each (1mg)
Each (1mg) - $916.69
$916.69
Each (1mg)
$916.69
Minimum order quantity is 1
Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
M-2405.0005BA
4029459.0005
5 mg
M-2405.0005
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Log in for availability
Each (5mg)
Each (5mg) - $3,661.82
$3,661.82
Each (5mg)
$3,661.82
Minimum order quantity is 1
Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.